Genomic 'hotspots' offer clues to causes of autism, other disorders

Dec. 20, 2012 ? An international team, led by researchers from the University of California, San Diego School of Medicine, has discovered that "random" mutations in the genome are not quite so random after all. Their study, to be published in the journal Cell on December 21, shows that the DNA sequence in some regions of the human genome is quite volatile and can mutate ten times more frequently than the rest of the genome. Genes that are linked to autism and a variety of other disorders have a particularly strong tendency to mutate.

Clusters of mutations or "hotspots" are not unique to the autism genome but instead are an intrinsic characteristic of the human genome, according to principal investigator Jonathan Sebat, PhD, professor of psychiatry and cellular and molecule medicine, and chief of the Beyster Center for Molecular Genomics of Neuropsychiatric Diseases at UC San Diego.

"Our findings provide some insights into the underlying basis of autism -- that, surprisingly, the genome is not shy about tinkering with its important genes" said Sebat. "To the contrary, disease-causing genes tend to be hypermutable."

Sebat and collaborators from Rady Children's Hospital-San Diego and BGI genome center in China sequenced the complete genomes of identical twins with autism spectrum disorder and their parents. When they compared the genomes of the twins to the genomes of their parents, the scientists identified many "germline" mutations (genetic variants that were present in both twins but not present in their mother or father).

Nearly 600 germline mutations -- out of a total of 6 billion base pairs -- were detected in the 10 pairs of identical twins sequenced in the study. An average of 60 mutations was detected in each child.

"The total number of mutations that we found was not surprising," said Sebat, "it's exactly what we would expect based on the normal human mutation rate." What the authors did find surprising was that mutations tended to cluster in certain regions of the genome. When the scientists looked carefully at the sites of mutation, they were able to determine the reasons why some genomic regions are "hot" while other regions are cold.

"Mutability could be explained by intrinsic properties of the genome," said UC San Diego postdoctoral researcher Jacob Michaelson, lead author of the study. "We could accurately predict the mutation rate of a gene based on the local DNA sequence and its chromatin structure, meaning the way that the DNA is packaged."

The researchers also observed some remarkable examples of mutation clustering in an individual child, where a shower of mutations occurred all at once. "When multiple mutations occur in the same place, such an event has a greater chance of disrupting a gene," said Michaelson.

The researchers surmised that hypermutable genes could be relevant to disease. When they predicted the mutation rates for genes, the authors found that genes that have been linked to autism were more mutable than the average gene, suggesting that some of the genetic culprits that contribute to autism are mutation hotspots.

The authors observed a similar trend for other disease genes. Genes associated with dominant disorders tended to be highly mutable, while mutation rates were lower for genes associated with complex traits.

"We plan to focus on these mutation hotspots in our future studies," said Sebat. "Sequencing these regions in larger numbers of patients could enable us to identify more of the genetic risk factors for autism."

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The above story is reprinted from materials provided by University of California - San Diego.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jacob?J. Michaelson, Yujian Shi, Madhusudan Gujral, Hancheng Zheng, Dheeraj Malhotra, Xin Jin, Minghan Jian, Guangming Liu, Douglas Greer, Abhishek Bhandari, Wenting Wu, Roser Corominas, ?ine Peoples, Amnon Koren, Athurva Gore, Shuli Kang, Guan?Ning Lin, Jasper Estabillo, Therese Gadomski, Balvindar Singh, Kun Zhang, Natacha Akshoomoff, Christina Corsello, Steven McCarroll, Lilia?M. Iakoucheva, Yingrui Li, Jun Wang, Jonathan Sebat. Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation. Cell, 2012; 151 (7): 1431 DOI: 10.1016/j.cell.2012.11.019

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/wIwFTSbWH3U/121220143516.htm

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GM to buy stake from Treasury; government may lose billions

(Reuters) - The U.S. Treasury plans to sell its stake in General Motors Co over the coming year, all but assuring a multibillion-dollar loss in a move that will end the automaker's "Government Motors" era.

Treasury's plan - a two-step process that includes a $5.5 billion stock sale to GM - is part of a broader push to wind down the controversial financial bailout under the Troubled Asset Relief (TARP) program. TARP was created by former president George W. Bush to prevent the collapse of the U.S. banking industry during the 2007-2009 financial crisis.

The planned GM sale will raise the proceeds that Treasury has recovered to $28.6 billion of the $50 billion bailout GM received. With $20.9 billion left from the original bailout, the government would have to sell its remaining shares at an average price of $69.72 to break even.

GM shares were up 7.1 percent at $27.31 on Wednesday afternoon on the New York Stock Exchange.

If Treasury, which will reduce its stake to about 19 percent when the buyback closes this month from about 26 percent at present, sold its remaining stock at the price GM is paying now, it would come up short by more than $12 billion.

"GM wins," Jefferies analyst Peter Nesvold said, pointing to the elimination of the government stake that has been acting as a drag on the stock price and to eventual higher earnings per share. "From a government standpoint, it's a mixed bag, but they went into it to save jobs, not as an investment." He said the buyback was lower than the $30 a share he had expected at the very least and was occurring earlier than anticipated.

GM's planned buyback of 200 million shares will give it more freedom from government oversight and likely result in a sales boost as some consumers unhappy over the U.S. taxpayer-funded bailout give the automaker a second look, GM Chief Financial Officer Dan Ammann said.

"This is very attractive to the company, to our shareholders," he told reporters at GM's Detroit headquarters. "It obviously brings some clarity and certainty around the U.S. Treasury exit.

"It's obviously good for the business in terms of continuing to remove the perception of government involvement in the company, which is going to be good for sales," he said, also noting that the reduced share count would boost earnings.

GM approached Treasury officials after the U.S. presidential election in November, but was rebuffed when it offered only to pay market value for the government's stock, according to a senior Treasury official. Treasury rejected a second offer of a small premium before the sides finalized the deal on Tuesday afternoon, said the Treasury official, who asked not to be identified discussing the negotiations.

"We've always looked at this as balancing speed of exit with maximizing return, and GM basically made us what we felt was a very attractive offer," the Treasury official said.

TARP TRIP NEARS END

TARP was approved by Congress as a $700 billion program, though Treasury eventually disbursed $418 billion. On Wednesday it said it had recovered $381 billion to date, or about 90 percent.

"TARP was always meant to be a temporary, emergency program. The government should not be in the business of owning stakes in private companies for an indefinite period of time," Treasury Assistant Secretary Timothy Massad said in a statement.

"Moving to exit our investment in GM within the next 12 to 15 months is consistent with our dual goals of winding down TARP as soon as practicable and protecting taxpayer interests."

Under the deal, GM will pay $27.50 a share for the Treasury-held shares, representing a 7.9 percent premium on Tuesday's closing price.

Treasury said it will then sell its remaining stake of about 300.1 million shares "through various means in an orderly fashion," and could begin the process, including sales on the open market, as soon as January.

The auto giant was dubbed "Government Motors" by many critics after it received its bailout package as part of the bankruptcy restructuring in 2009 under TARP.

Treasury's plans echo other recent moves. On Tuesday, Treasury said it would largely sell its remaining shares in bailed-out banks over the coming 12 to 15 months. Last week it sold the last of its common stock in American International Group Inc at a profit.

This also would close Treasury's involvement with the U.S. auto sector. In June 2011, the agency sold its remaining 6 percent stake in Chrysler to Italy's Fiat SpA , which controls the U.S. automaker.

U.S. President Barack Obama heavily promoted his decision to use public funds to rescue the auto industry and save jobs as he campaigned for re-election in swing states like Michigan and Ohio. Voters in both states backed him again in the November 6 election, providing critical support in his victory.

Treasury officials reiterated on Wednesday that the auto bailout saved more than 1 million U.S. jobs and was not meant to turn a profit.

With Treasury's planned exit from GM, auto lender Ally Financial Inc will be the last major TARP recipient that has not yet paid back the government. Of the $17 billion it owes, Ally has paid back $5.8 billion.

SHOWING CONFIDENCE

Separately on Wednesday, Canada Finance Minister Jim Flaherty said his country had no immediate plans to sell its stake in GM. Canada and the province of Ontario have a combined 9 percent stake.

Ammann said the move and resulting Treasury plans will remove a "significant overhang" on the stock that has hurt sales and bring an "element of closure" to the bailout. Company research suggests eliminating the Treasury stake would benefit sales, he said.

Ammann said the deal was good for shareholders, when asked whether GM might be sued for paying Treasury a higher price than where the stock was trading at the time of the announcement.

However, one large shareholder loved the deal, as a spokesman for hedge fund manager David Einhorn said: "We applaud GM management for unlocking shareholder value by releasing excess capital and beginning a resolution of the government stake overhang."

Barclays analyst Brian Johnson said that once the government reduces its stake, GM likely will be eligible for inclusion in the Standard & Poor's 500 index , which could serve as a catalyst to drive up the company's stock price.

GM will end the year with estimated liquidity of about $38 billion, even after the deal, Ammann said. That will add to earnings per share by reducing the number of outstanding shares by about 11 percent.

Ammann said the deal will be funded through cash and not tap in to the $11 billion credit line GM secured last month.

Citi analyst Itay Michaeli said the deal showed GM's confidence in its ability to generate cash despite worries about the U.S. economy and the recession in Europe. "The ability to spend this amount of money on a share buyback shows they are putting their money where their mouth is," he said.

The deal also made a winner of Ammann, considered one of a handful of GM executives who could succeed Chief Executive Dan Akerson. Ammann, along with Akerson and GM general counsel Michael Millikin, negotiated the deal with Massad, Treasury Secretary Timothy Geithner, chief investment officer Matt Pendo and government attorneys over several weeks, according to the senior Treasury official and another person familiar with the talks who asked not to be identified.

Ammann did not provide details of the talks with Treasury, when asked whether negotiations picked up following the presidential election. Analysts said Treasury likely did not want this deal to be turned into a political issue.

Treasury also may have wanted to wait for the unveiling of the critical full-size pickup trucks that will go on sale next year, analysts said. GM showed the new Chevrolet Silverado and GMC Sierra on December 13.

GM will take a charge of about $400 million in the fourth quarter tied to the buyback.

In addition, Treasury relinquished certain governance rights, including required levels of U.S. manufacturing and barring the purchase of corporate jets, Ammann said. Senior executive payment caps under TARP remain in place.

"For GM management, it was very important to get out from under the 'Government Motors' moniker," Morgan Stanley analyst Adam Jonas said.

(Additional reporting by Alister Bull in Washington, Jennifer Ablan in New York, Paul Lienert in Detroit and Rick Rothacker in Charlotte, North Carolina; Editing by Gerald E. McCormick, Jeffrey Benkoe, Tim Ahmann, Matthew Lewis and Jan Paschal)

Source: http://news.yahoo.com/gm-buy-stake-treasury-plans-full-exit-holdings-131103066--finance.html

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Barca coach suffers cancer relapse

BARCELONA: Barcelona coach Tito Vilanova has suffered a relapse of cancer a year after surgeons removed a tumour from his salivary gland, the club said Wednesday, in a potentially bitter blow for the Spanish league leaders.

Messages of support poured in for the 44-year-old, whose team is flying nine points high at the top of La Liga after the club confirmed media reports in Spanish sports dailies.

The Catalan giants said in an initial statement that a scheduled news conference for Wednesday lunchtime with Barca president Sandro Rossell had been cancelled, as had a planned Christmas meal with the media.

They then added that Vilanova would have surgery on Thursday and thereafter also undergo "around six weeks of radiotherapy and chemotherapy," according to a statement on the club's website, fcbarcelona.es.

Spanish newspaper El Economista citing sources close to the club said Vilanova's assistant Jordi Roura would take over his duties in his absence. Various media said Vilanova was due to be operated on again imminently.

The development comes at a dramatic time for Barcelona, one of the world's most successful football teams. They have made their best ever start to the league season, while their fierce rivals and title holders Real Madrid are suffering a malaise.

Jose Mourinho's Real are 13 points adrift in third place and rattled by reports of internal squabbles.

Real Madrid preempted any official announcement on Vilanova's condition Wednesday by wishing Vilanova well in a statement.

"Real Madrid wishes to express all its support, love and affection for Barcelona's coach Tito Vilanova, to whom it wishes a quick recovery," it said. "Real Madrid extends this support to his club and all his family."

On Twitter messages of support came from sporting figures including tennis champion Rafael Nadal who said: "All my strength and support to Tito Vilanova. We are with you to overcome this."

Vilanova has been Barca manager since the departure of his long-time comrade-in-arms Pep Guardiola in April this year.

He underwent an operation to remove a tumour on his parotid gland -- the largest of the salivary glands -- on November 22, 2011 and was back at work as Guardiola's deputy just 15 days later.

Vilanova has led Barcelona to the most successful start to a season in La Liga's history, with 15 wins and one draw in 16 matches so far.

They rule supreme over Spain's clubs, nine points ahead of runners-up Atletico Madrid, in large part due to Argentine talisman Lionel Messi, who has taken his tally for the calendar year to a record-breaking 90.

Vilanova played only briefly as a professional in Spain's top flight, notably with Celta Vigo, before turning to coaching at the end of his career and finding his way back to the club of his youth.

He came through Barcelona's youth ranks but after failing to break into the first team he continued his playing career with a number of lower league clubs before retiring in 2002.

He rejoined the Catalans as a youth coach in 2007, helping Barcelona's B side to promotion.

Vilanova was promoted to first team duties, working alongside Guardiola, for the 2008-2009 season, by the end of which the team had won six major trophies including the Champions League.

Reports of Vilanova's relapse emerged on the same day that a Catalan radio station and Mundo Deportivo said doctors had given the all-clear for Barcelona defender Eric Abidal to play again after undergoing a liver transplant on April 10.

The operation was conducted more than a year after a tumour was removed from his liver.

Source: http://www.dailystar.com.lb/Sports/Football/2012/Dec-19/199140-barca-coach-suffers-cancer-relapse.ashx

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3 Ways To Purchase Foreclosed Properties - Real Estate Marbles

Dec

20

December 20, 2012 | Leave a Comment

Foreclosure signThe process of buying a foreclosed home is slightly different from the process of buying a non-foreclosure home. ?If you want to invest in Santa Rosa foreclosures, therefore, it is important to understand the different ways by which to purchase a foreclosed home.

There are three main ways to buy a foreclosed home.

Buying before the auction
Some delinquent homeowners may want to sell their homes before facing an actual foreclosure.In this instance, the homeowner, in agreement with the lender, agrees to sell the home for less than the amount owed on the mortgage.This is called a short sale. Short sales are ?pre-foreclosures?, of sorts. By broadening your home search to include short sales, you can identify homes that may be sold at a discount.

Buying at the auction
Another way by which you can invest in foreclosure homes is by buying the home at auction. From area to area, the legal requirements for the sale of a foreclosed home at auction may differ. If you plan to buy at auction, you?ll want to be familiar with your area?s customary judicial proceedings.

Buying after the auction
Buying after the auction means buying bank-owned properties. This can be the most lucrative and safest means of investing foreclosure properties. This is because lenders often reduce the sales prices of their home inventory in order to ?sell it quickly?. It can be expensive for banks to own foreclosed homes, and few banks are equipped for managing owned homes. Check with your local real estate agent to see what, if any, bank-owned homes are available for sale in your area.

The process of buying a distressed home is different from the process of buying a ?traditional? one. Therefore, regardless of which path you follow to buy a foreclosed property, have an experienced real estate professional on your team.

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Source: http://realestatemarbles.com/emortgagesnews/2012/12/20/tips-to-buy-foreclosed-home/

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SIHS Nursing when was begging?.. and Usher song | Learn the ...

This video is Sool institute of health science .. it;s when I was studying in Nursing ? Plz watch it and take it ,,,, good day

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Source: http://health-ful-hints.com/2012/12/19/sihs_nursing_when_was_begging-_and_usher_song/

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Classes resuming in Newtown, minus Sandy Hook

A young girl waves as her school bus pulls into Hawley School, Tuesday, Dec. 18, 2012, in Newtown, Conn. Classes resume Tuesday for Newtown schools except those at Sandy Hook. Buses ferrying students to schools were festooned with large green and white ribbons on the front grills, the colors of Sandy Hook. At Newtown High School, students in sweatshirts and jackets, many wearing headphones, betrayed mixed emotions. Adam Lanza walked into Sandy Hook Elementary School in Newtown, Friday and opened fire, killing 26 people, including 20 children, before killing himself.(AP Photo/Jason DeCrow)

A young girl waves as her school bus pulls into Hawley School, Tuesday, Dec. 18, 2012, in Newtown, Conn. Classes resume Tuesday for Newtown schools except those at Sandy Hook. Buses ferrying students to schools were festooned with large green and white ribbons on the front grills, the colors of Sandy Hook. At Newtown High School, students in sweatshirts and jackets, many wearing headphones, betrayed mixed emotions. Adam Lanza walked into Sandy Hook Elementary School in Newtown, Friday and opened fire, killing 26 people, including 20 children, before killing himself.(AP Photo/Jason DeCrow)

Easton police officer J. Sollazzo clasps hands with a young student returning to Hawley School, Tuesday, Dec. 18, 2012, in Newtown, Conn. Classes resume Tuesday for Newtown schools except those at Sandy Hook. Buses ferrying students to schools were festooned with large green and white ribbons on the front grills, the colors of Sandy Hook. At Newtown High School, students in sweatshirts and jackets, many wearing headphones, betrayed mixed emotions. Adam Lanza walked into Sandy Hook Elementary School in Newtown, Friday and opened fire, killing 26 people, including 20 children, before killing himself.(AP Photo/Jason DeCrow)

Pallbearers carry the casket containing the body of James Mattioli into St. Rose of Lima Roman Catholic Church for funeral services, Tuesday, Dec. 18, 2012, in Newtown, Conn. Mattioli, 6, was killed when Adam Lanza walked into Sandy Hook Elementary School in Newtown, Conn., Dec. 14, and opened fire, killing 26 people, including 20 children, before killing himself.(AP Photo/Julio Cortez)

Easton police officer J. Sollazzo waves to returning children as their bus pulls into Hawley School, Tuesday, Dec. 18, 2012, in Newtown, Conn. Classes resume Tuesday for Newtown schools except those at Sandy Hook. Buses ferrying students to schools were festooned with large green and white ribbons on the front grills, the colors of Sandy Hook. At Newtown High School, students in sweatshirts and jackets, many wearing headphones, betrayed mixed emotions. Adam Lanza walked into Sandy Hook Elementary School in Newtown, Friday and opened fire, killing 26 people, including 20 children, before killing himself.(AP Photo/Jason DeCrow)

Mourners embrace outside of St. Rose of Lima Roman Catholic Church during funeral services for James Mattioli, Tuesday, Dec. 18, 2012, in Newtown, Conn. Mattioli, 6, was killed when Adam Lanza walked into Sandy Hook Elementary School in Newtown, Conn., Dec. 14, and opened fire, killing 26 people, including 20 children, before killing himself. (AP Photo/Julio Cortez)

(AP) ? With security stepped up and families still on edge in Newtown, students began returning to school Tuesday for the first time since last week's massacre, bringing a return of familiar routines ? at least, for some ? to a grief-stricken town as it buries 20 of its children.

A 6-year-old boy and a 6-year-old girl were laid to rest Tuesday, the latest in a long, almost unbearable procession of funerals. A total of 26 people were killed at Sandy Hook Elementary in one of the worst mass shootings in U.S history.

Buses ferrying students to schools were festooned with large green-and-white ribbons on the front grills, the colors of Sandy Hook, as classes resumed for all Newtown schools except the stricken elementary school.

At Newtown High School, students in sweat shirts and jackets, many wearing headphones, betrayed mixed emotions. Some waved at or snapped photos of the assembled media horde, and others appeared visibly shaken.

"There's going to be no joy in school," said 17-year-old senior P.J. Hickey. "It really doesn't feel like Christmas anymore."

At St. Rose of Lima Catholic Church in Newtown, back-to-back funerals were held for first-graders James Mattioli and Jessica Rekos, the first of eight to be held in the coming days at the church.

As mourners gathered outside, a motorcade led by police motorcycles arrived for the funeral of little James, who especially loved recess and math, and whose family described as a "numbers guy" who couldn't wait until he was old enough to order a foot-long Subway sandwich.

The service had not yet concluded when mourners began arriving for the funeral of Jessica, who loved horses and was counting the years until she turned 10, when her family had promised her a horse of her own. For Christmas, she had asked Santa for new cowgirl boots and hat.

"We are devastated, and our hearts are with the other families who are grieving as we are," her parents, Rich and Krista Rekos, said in a statement.

Traffic in front of the church slowed to a crawl as police directed vehicles into the church parking lot. At one point a school bus carrying elementary students became stuck in traffic. The children pressed their faces into the windows, sadly watching as mourners assembled at the church

At the high school, students didn't expect to get much work done Tuesday and spent much of the day talking about the terrible events of last week carried out by 20-year-old Adam Lanza.

"We're going to be able to comfort each other and try and help each other get through this because that's the only way we're going to do it. Nobody can do this alone," Hickey said.

Sophomore Tate Schwab agreed. "It's definitely better than just sitting at home watching the news," he said. "It really hasn't sunk in yet. It feels to me like it hasn't happened. It's really weird."

As for concerns about safety, the students were defiant.

"This is where I feel the most at home," Hickey said. "I feel safer here than anywhere else in the world."

Some parents kept their children at home anyway Tuesday, as local police and school officials planned how and where to increase security. State police said they were on alert for threats and hoaxes.

One Newtown school, Head O'Meadow Elementary, was reportedly locked down Tuesday due to an unspecified threat. The principal told parents to keep their children home, according to a letter from the principal published by WFSB-TV.

Authorities say the horrible events of Friday began when Lanza shot his mother, Nancy, at their home, then took her car and some of her guns to nearby Sandy Hook Elementary, where he broke in and opened fire, killing 20 children and six adults before turning the gun on himself.

A Connecticut official said the mother, a gun enthusiast who practiced at shooting ranges, was found dead in her pajamas in bed, shot four times in the head with a .22-caliber rifle.

Lanza was wearing all black, with an olive-drab utility vest with lots of pockets, during the attack.

As investigators worked to figure out what drove him to lash out with such fury ? and why he singled out the school ? federal agents said that he had fired guns at shooting ranges over the past several years, though there was no evidence he had done so recently.

Debora Seifert, a spokeswoman for the federal Bureau of Alcohol, Tobacco, Firearms and Explosives, said both Lanza and his mother fired at shooting ranges, sometimes visiting them together.

"We do not have any indication at this time that the shooter engaged in shooting activities in the past six months," Seifert said.

Investigators have found no letters or diaries that could explain the attack.

Whatever his motives, normalcy will be slow in returning to Newtown. Classes were canceled districtwide Monday.

Dan Capodicci, whose 10-year-old daughter attends the school at St. Rose of Lima church, said it was time for her to get back to classes.

"It's the right thing to do. You have to send your kids back. But at the same time I'm worried," he said. "We need to get back to normal."

The district has made plans to send surviving Sandy Hook students to Chalk Hill, a former middle school in the neighboring town of Monroe. Sandy Hook desks that will fit the small students were being taken there, and tradesmen were donating their services to get the school ready within a matter of days.

With Sandy Hook Elementary still designated a crime scene, state police Lt. Paul Vance said it could be months before police turn the school back over to the district.

Lanza is believed to have used a Bushmaster AR-15-style rifle, a civilian version of the military's M-16. It is similar to the weapon used in a recent shopping mall shooting in Oregon and other deadly attacks around the U.S. Versions of the AR-15 were outlawed in this country under the 1994 assault weapons ban, but the law expired in 2004.

Private equity firm Cerberus Capital Management announced Tuesday it plans to sell its stake in Freedom Group, maker of the Bushmaster rifle, following the school shootings.

Cerberus said in a statement that it was deeply saddened by Friday's events, and that it will hire a financial adviser to help with the process of selling its Freedom Group interests.

The outlines of a national debate on gun control have begun to take shape. At the White House, spokesman Jay Carney said curbing gun violence is a complex problem that will require a "comprehensive solution."

Carney did not offer specific proposals or a timeline. He said President Barack Obama will meet with law enforcement officials and mental health professionals in coming weeks.

New York Mayor Michael Bloomberg, flanked by shooting survivors and relatives of victims of gunfire around the country, pressed Obama and Congress to toughen gun laws and tighten enforcement after the Newtown massacre.

"If this doesn't do it," he asked, "what is going to?"

At least one senator, Virginia Democrat Mark Warner, said Monday that the attack in Newtown has led him to rethink his opposition to the ban on assault weapons.

West Virginia Sen. Joe Manchin, a Democrat who is an avid hunter and lifelong member of the National Rifle Association, said it's time to move beyond the political rhetoric and begin an honest discussion about reasonable restrictions on guns.

"This is bigger than just about guns," he added. "It's about how we treat people with mental illness, how we intervene, how we get them the care they need, how we protect our schools. It's just so sad."

___

Contributing to this report were Associated Press writers Allen G. Breed, Helen O'Neill, John Christoffersen, Pat Eaton-Robb and Katie Zezima in Newtown; and Christine Armario in Miami.

Associated Press

Source: http://hosted2.ap.org/apdefault/386c25518f464186bf7a2ac026580ce7/Article_2012-12-18-Connecticut-School-Shooting/id-0647a18cbc9246a8b938ecf004fe9239

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The NBA has filed for 4 trademarks ( sucks to be on New Orleans)

The NBA has filed for 4 trademarks ( sucks to be on New Orleans)

Posted by: Eric Ostler on December 18th, 2012

The author's views are entirely his or her own and may not reflect the views of the Utah Jazz.

The NBA has filed trademarks for the New Orleans Pelicans, amongst four other potential nicknames on behalf of the New Orleans Hornets NBA Limited Partnership.

The Rougarou, Mosquitos, Swamp Dogs and Bullsharks are the other nicknames that have been filed for trademark.

A swamp dog is a Cajun nickname for an alligator, while Rougarou refers to a beast from Louisiana folklore.

New Orleans will likely adopt a red, blue and gold color scheme.

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Source: http://www.utahjazz360.com/ericost/the-nba-has-filed-for-4-trademarks-sucks-to-be-on-new-orleans/

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Video: Honest conversation about gun control needed

Hollywood struggles with gun violence

Guns and shootings are as much a part of Hollywood plots as special effects and makeup. But after last week's shootings in Newtown, Conn., entertainment executives have been scrambling to make changes to avoid looking insensitive to the tragedy.

Source: http://video.msnbc.msn.com/hardball/50241481/

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Instagram realizes it needs to start making money, decides to do it with your photos and identity

Instagram realizes it needs to start making money, decides to do it with your photos and identity

Instagram, the popular online photo filtering, blurring, and sharing community, has changed its terms of service to allow them to share your data with their new owner, Facebook, its affiliates and advertisers, and use your photographs and identity in advertising without your consent, and without any revenue sharing.

Some or all of the Service may be supported by advertising revenue. To help us deliver interesting paid or sponsored content or promotions, you agree that a business or other entity may pay us to display your username, likeness, photos (along with any associated metadata), and/or actions you take, in connection with paid or sponsored content or promotions, without any compensation to you. If you are under the age of eighteen (18), or under any other applicable age of majority, you represent that at least one of your parents or legal guardians has also agreed to this provision (and the use of your name, likeness, username, and/or photos (along with any associated metadata)) on your behalf.

Depending on whose take you read, this is either a profound bait-and-switch and betrayal or an obvious reality of online business that anyone with a brain should have seen coming. And, as usual, it's both. It's the proverbial scorpion given a ride across the river, that stings us and leaves us both to drown, because that is its nature and we knew what it was when we picked it up.

We're human. No matter how much our rational brain hears and understands that we never get something for nothing, our cheapskate brains just can't resist jumping into bed with any online service that promise us some form of like-minded community with a twist. Free-as-in-Google has become a convenient way for us to "pay" with things far less tangible than money, though also sometimes far more valuable -- our time, our attention, our personal information, our location, our privacy, our identity.

Some of us don't care about any of those things, so "free" services are an incredible bargain. Our money stays in our pocket and our data becomes needles and in ever-growing haystack. Others of us care about those things a great deal, so "free" services are prohibitively expensive. We'd rather pay money and stay out of the haystack.

Instagram isn't innocent. They knew they'd have to make money at some point, and whether or not this was always their plan, some form of this had to have always been their plan, just like Twitter, Facebook, Google, and others before them, and no doubt others after them. Reckless growth needs to be paid for eventually, and users are the easiest and most valuable product hawk.

We're not innocent either. We knew Instagram would have to make money at some point as well. It's happened to us before with Twitter, Facebook, Google, and others, and we'll no doubt let it happen again. Getting sold just seems like so much better a deal than having to buy.

If the changes in Instagram's terms of service are deal-breakers for you, you can close your account and look into alternatives, though hopefully with eyes open more widely.

If the changes don't bother you, then you can just keep on keeping on, and I look forward to seeing the grainy, color-filtered, tilt-shifted, picture of you, your pet, and your waffles, with your name on it, as part of a Facebook singles ad in my sidebar sometime soon.

(I kid. Not really.)

Source: Instagram

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/JmFwYt3kOZs/story01.htm

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Call for Papers: International Workshop on Managing Technical Debt

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