Botanical compound could prove crucial to healing influenza

[ Back to EurekAlert! ] Public release date: 18-Jul-2012
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Contact: Tiffany Trent
ttrent@vbi.vt.edu
540-231-6822
Virginia Tech

Virginia Tech researchers have discovered that abscisic acid has anti-inflammatory effects in the lungs as well as in the gut

Building on previous work with the botanical abscisic acida, researchers in the Nutritional Immunology and Molecular Medicine Laboratory (NIMML) have discovered that abscisic acid has anti-inflammatory effects in the lungs as well as in the gut. The results will be published in the Journal of Nutritional Biochemistry.

"While the immune effects of abscisic acid are well understood in the gut, less was known about its effects in the respiratory tract. We've shown definitively that not only does abscisic acid ameliorate disease activity and lung inflammatory pathology, it also aids recovery and survival in influenza-infected mice," said Raquel Hontecillas, Ph.D., study leader, assistant professor of immunology at Virginia Bioinformatics Institute, and co-director of NIMML.

Influenza accounts for anywhere from 3,000 to 49,000 deaths per year in the United States alone, according to the Centers for Disease Control. It is difficult to treat if not caught immediately; antivirals usually become ineffective after the virus incubation period has passed and resistance to antiviral drugs poses a serious public health problem in the face of outbreaks. Abscisic acid, however, has been shown to be most effective at about seven to ten days into the infection, targeting the immune response rather than the virus itself, which many researchers feel is a safer way to reduce flu-associated fatalities.

"Most drugs for respiratory infections target the virus itself, rather than the inflammatory responses caused by the virus. Abscisic acid activates peroxisome proliferator-activated receptor-gamma, a receptor that aids in reducing inflammation, through a newly identified pathwaya but it does so without the side effects of other agonists like thiazolidinediones, which are known to have strong adverse side effects. The development of complementary and alternative Medicine approaches that modulate the host response has great promise in decreasing respiratory damage caused by influenza or other respiratory pathogens," said Josep Bassaganya-Riera, Ph.D., director of NIMML and professor of nutritional immunology at the Virginia Bioinformatics Institute.

From this and previous research, it's clear that abscisic acid could yield a novel new way to combat inflammatory disease, both in the gut and the respiratory tract. By using host-targeted strategies to mediate disease, alternate pathways can be established to activate immune responses without the deadly side effects of many drugs currently on the market.

###

This research was supported by award number R01AT004308 of the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health awarded to Josep Bassaganya-Riera, the Virginia Bioinformatics Institute-Fralin CRI grants program to Raquel Hontecillas, and funds from the Nutritional Immunology and Molecular Medicine Laboratory.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 18-Jul-2012
[ | E-mail | Share Share ]

Contact: Tiffany Trent
ttrent@vbi.vt.edu
540-231-6822
Virginia Tech

Virginia Tech researchers have discovered that abscisic acid has anti-inflammatory effects in the lungs as well as in the gut

Building on previous work with the botanical abscisic acida, researchers in the Nutritional Immunology and Molecular Medicine Laboratory (NIMML) have discovered that abscisic acid has anti-inflammatory effects in the lungs as well as in the gut. The results will be published in the Journal of Nutritional Biochemistry.

"While the immune effects of abscisic acid are well understood in the gut, less was known about its effects in the respiratory tract. We've shown definitively that not only does abscisic acid ameliorate disease activity and lung inflammatory pathology, it also aids recovery and survival in influenza-infected mice," said Raquel Hontecillas, Ph.D., study leader, assistant professor of immunology at Virginia Bioinformatics Institute, and co-director of NIMML.

Influenza accounts for anywhere from 3,000 to 49,000 deaths per year in the United States alone, according to the Centers for Disease Control. It is difficult to treat if not caught immediately; antivirals usually become ineffective after the virus incubation period has passed and resistance to antiviral drugs poses a serious public health problem in the face of outbreaks. Abscisic acid, however, has been shown to be most effective at about seven to ten days into the infection, targeting the immune response rather than the virus itself, which many researchers feel is a safer way to reduce flu-associated fatalities.

"Most drugs for respiratory infections target the virus itself, rather than the inflammatory responses caused by the virus. Abscisic acid activates peroxisome proliferator-activated receptor-gamma, a receptor that aids in reducing inflammation, through a newly identified pathwaya but it does so without the side effects of other agonists like thiazolidinediones, which are known to have strong adverse side effects. The development of complementary and alternative Medicine approaches that modulate the host response has great promise in decreasing respiratory damage caused by influenza or other respiratory pathogens," said Josep Bassaganya-Riera, Ph.D., director of NIMML and professor of nutritional immunology at the Virginia Bioinformatics Institute.

From this and previous research, it's clear that abscisic acid could yield a novel new way to combat inflammatory disease, both in the gut and the respiratory tract. By using host-targeted strategies to mediate disease, alternate pathways can be established to activate immune responses without the deadly side effects of many drugs currently on the market.

###

This research was supported by award number R01AT004308 of the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health awarded to Josep Bassaganya-Riera, the Virginia Bioinformatics Institute-Fralin CRI grants program to Raquel Hontecillas, and funds from the Nutritional Immunology and Molecular Medicine Laboratory.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-07/vt-bcc071812.php

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Catholic Eric Bolling Tells Atheist Baseball Fans To "Stay Out Of The Ballpark"

By his own standards and the definition of Fox News Insider, Eric Bolling is a devout Catholic who regularly attends mass and lights candles for his friends. And like the *Catholic Inquisition,?he has a very low tolerance for those who do not believe as he does. He once?kicked an atheist off his Fox Business?show because he thought his guest denigrated Jesus. Of course, Jesuit educated Bolling denigrates President Obama, liberals, Muslims and that's all good; but I digress. But Bolling's bias against atheists is not an anomaly on Fox News - the "fair and balanced" news network that has atheists on the top of its enemies list along with all those groups that do not hew to the orthodoxy of the GOP right wing. This morning, in yet another attempt to smear those evil, Jesus hating atheists, Fox & Friends provided Bolling with yet another opportunity to express his distaste for those godless beings. Torquemada? Torquemada?

In typical fashion, this morning's Fox & Friends picked up on a story being publicized by Fox's "fundamentalist barking dog" Todd Starnes, a gun, Jesus, and barbecue loving and homo hating right winger whose task in life is to root out affronts to Christianity. He also attends gay pride parades where he oogles the leather chaps and thongs; but I digress. The newest affront to Christianity is, OMG, a baseball team that is celebrating "atheist night" in the same manner that they celebrate Christian and Jewish nights. In August, the minor league team, the St. Paul Saints, will be the St. Paul "ain'ts." Not only will the team jerseys have "ain't" on their back but American Atheist Foundation president, David Silverman, who appears on Fox to defend Fox's accusations against atheists, will throw out the first pitch. Starnes, whose article?is sourced on Fox Nation,?says that this is "bashing" the Christian faith. So not surprisingly, the fundamentalist braying jack asses on Fox & Friends took up the cross in a casual discussion during which the Fox patented "we think atheists suck" message was advanced.

Uber Christian Steve Doocy reported the back story while the chyron read "Foul Ball or Fair Game Minor League Team Holds Atheist Day." As he spoke, Bolling made some unintelligible noise in the background and fellow uber Christian Gretchen Carlson laughed in a?not so happy way. In introducing a quote from a Minnesota atheist, her voice dripped with venom as she said his name. As she read the part of the quote about how "ain't" was a word "that everybody could relate to" and we ain't got a belief in God," she sounded sad.

This was the cue for Bolling's righteous rant. As he started, Gretchen laughed and did happy Gretch face. Bolling loudly brayed: "And you ain't got to go to that ball park and you ain't gotta, you know what you can do, you can pray for rain that day which all of us good Christians will be praying for rain. Come on, really, baseball, American, all American, apple pie STAY OUT OF THE BALLPARK. Don't bring the religion into the ballpark, let these people have a good time..." He joked that the "ain't's" was a scab team and that was funny but "this, not so funny for me." Gretchen's happy face disappeared when she read a atheist's blog comment about how the seventh inning stretch would include singing of "dog bless America." She harrumphed and said "that might be taking it a little too far."

Bollling, who cited "American" traditions," doesn't seem to realize that this country was founded on the idea that people would be free to worship or not worship as they please. But obviously the idea of tolerance is somehow alien, and possibly threatening, to the "devout Catholic" Bolling who thinks that the only?good American is a god worshipping one.?It's all a matter of faith and while Bolling?is free to believe as he does,?he doesn't have the same respect for those whose world view is different. He actually thinks that the presence of atheists, at a ball game, interferes with the "good time" had by others? His hatred is so intense that he's wishing rain on the day of the game. Can you imagine his indignation if Bill Maher did the same for some Catholic activity? Oh well, he goes to mass and lights candles so his soul must be so spotless. Ya think!

And memo to Bolling - if you don't like atheists, don't go to the game!

* Now known as the "Congregation for the Doctrine of the Faith." The former head, Cardinal Ratizinger, is now Pope.

Source: http://www.newshounds.us/20120718_catholic_eric_bolling_tells_atheist_baseball_fans_to_stay_out_of_the_ballpark

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Heart ~ Fit Syracuse - Personal Training, Nutritional Health and ...

4 days. 15 events.? Ocean swim, long runs, short sprints, rope climbs, sled push, sledge hammers, pullups, squats, muscle-ups, ring dips, cleans, jumping, pushing, pulling...? The athletes at the 2012 Reebok CrossFit Games were put through the ringer, and for two athletes it all came down to the final event.? The winner would earn the final spot on the top podium and $250,000. (jump to minute 5:00)

Source: http://www.fitsyracuse.com/2012/07/heart.html

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Reader Clarifies Not All Relationships Are Marriage | NOM Blog

July 16, 2012 at 11:00 am

?

Elizabeth Schreiner of Lakeville, MN writes to the editor of the Sun This Week:

Your Sun This week of July 6 had some letters to the editor that spiked comment in me. The ?other side of the coin? so to speak.

I don?t know how anyone can get so mixed up in their thinking over the proposed marriage amendment. I keep reading Veda Kanitz?s letter and think she should do more research on the real issue.

Her letter states that Sherry and Barb are two beautiful ?children of the universe? in a beautifully committed relationship, but I say that is what it is. It?s a relationship, but not a marriage.

The proposed amendment doesn?t try to change their personal life or their personal choices or desires, so what?s the big fuss? The amendment shouldn?t and doesn?t bother their routine at all. They had and have the freedom to choose their way of life and good luck to them.

Source: http://www.nomblog.com/25323/

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Nexus 7 pre-orders start shipping in UK and Canada

Nexus 7 preorders start shipping in UK and Canada

The Nexus 7 machine is in full swing. According to Google, all pre-orders placed by Friday the 13th in the US and Australia have been filled as of today (though some may still be en route), and our friends in the UK and Canada should be receiving theirs soon enough. Deliveries are currently heading out in waves, putting 7-inches of Jelly Bean in the hands of eager "footie" fans and beneficiaries of socialized medicine. Have you gotten your shipment notification yet? Let us know in the comments.

Update: Google has since changed the wording on its site and, unfortunately, not "all" US and Australian have shipped. Now it's just "many."


[Thanks, Andrew]

Filed under:

Nexus 7 pre-orders start shipping in UK and Canada originally appeared on Engadget on Tue, 17 Jul 2012 10:31:00 EDT. Please see our terms for use of feeds.

Permalink TechnoBuffalo, Android Central  |  sourceGoogle  | Email this | Comments

Source: http://www.engadget.com/2012/07/17/nexus-7-pre-orders-start-shipping-in-uk-and-canada/

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What Do We Do Next? ? Love Notes for Long Distance Connections

Love can be expressed in many different methods. One amazing method of expressing love is writing love notes. Creating notes, to be certain, a letter is the classics among all the other ways of showing one?s undying love. A long period before, partners, who are far away from one another, can only connect through words and love notes by sending it via post. By writing, you are able to show your love and desiring one another without hesitation.Writing words play a very important part in a long distance connection. Love records for long distance relationships have become powerful because you don?t normally see one another in comparison to normal partners. Because the years pass by, romantic love letters developed into romantic fax to romantic messages. But for many people, there?ll be nothing much better than the old and tested passionate love letters.Long distance relationships are believed to not last and only crash. Yes, it is hard to stay a distance relationship and survive it yet, it is not difficult. The initial important ingredient for a long distance relationship to be successful is conversation. Relationship requires care, especially the long distance one. Since couples in long distance relationships need more attention, writing love notes can provide little compensation to someone far from their other half.For those that are having difficulty with writing, and is eating time thinking of any ideas on what to write, here are some hints on the way you can deliver love notes full of TLC match for long distance relationships.There are different kinds of notes that can certainly make her feel special and so precious. With the reputation of sending texting because it is fast and cheap, love records can be fast and cheap. Deliver her I love you in the proper execution of SMS everyday to produce her feel like you are just a text away. Don?t send her common quotes which seem insincere. You can just tell her how you feel and it can surely make her feel admired for the rest of the day. When you certainly are an one who isn?t really busy, instead of texting send her love notes via email. Get it done everyday and she?ll certainly appreciate you more. She?ll never feel alone reading easy special notes from you.What to publish is yet another issue accessible. Here is a simple information on how to create successful, nice and passionate love notes for long distance relationships.Presentation ? You?ve to provide it simple, desirable or extravagant. Use aromatic or beautifully made stationery to produce it more respectable. Use black or brown ink, avoid orange, red, yellow or green pencils for it is harder to learn and see.
Special Music ? Sweet music can make the ambiance romantic, consequently it can make you imagine of good and romantic items to write. Your feeling can be activated by dim light to quickly fill your heart out.
The Date ? Always remember to place a time with this page may be an excellent keepsake in the history of your connection.
Start with a ? Use your partner?s first name in addressing her and use a special salutation to create the letter more passionate. You may also use pet names or his/her name depending on the dilemma.
Allow Your Emotion Flow ? Don?t hesitate to state yourself. Be sincere and honest on which you really wish to say. Believe it or not, truth and candor may be sensed also from words.
Close it with Love ? Be cool and remember those three magic words.
Writing love notes for long distance relationships can spot miles regardless of how far it?s. Love does not have any restrictions.

Come to our website for more information about long distance love

Source: http://whatdowedonext.org/?p=37290

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Copywriting Missteps That You Ought To Attempt To Avoid

This article has been viewed 10 times.

One of the best solutions to improve any Online business is that will put out some excellent copywriting which will draw an excellent audience. You know that words sell and when you can write a good copy then you can definitely develop a fortune together with your business. Particularly when looking at direct response selling or search engine optimisation, in the world of internet marketing, copy is king. Whether it?s MLM, selling physical products on the internet, or your service, you need to write so that people get convinced to buy within you. It isn?t even necessary to be as careful of the grammar that you just learned while in school when copywriting. You need to actually write like you speak; that way as soon as your target group is reading whatever you wrote, they feel as if you are actually speaking with them. Like all disciplines, there are numerous guidelines that really must be followed to write down effectual copy. In terms of landing your prospective buyers, you simply can?t risk making any mistakes. In this post we?ll be researching tips on how to avoid making common copywriting mistakes.

In today?s world, consumers want up to date information they will can immediately utilized. They would like to have the information quickly, so guarantee the copy grabs their attention. Thus, making this why, when you wish to carry the interest of the reader, you should concentrate on making a great headline to your copy. Titles are likely to be overlooked until the eleventh hour by many copywriters? certainly one of the biggest errors they could make. In order to pointedly direct the crowd to your article and supply advisable of the items there are here, effective headlines include the only formula for achievement. A dull headline which only bores people may be the worst mistake a copywriter might make. A big extent of the sales will go directly to you, exclusively due to your headline. It?s because of this that this quality of your respective headline is of supreme importance and should get significant consideration. Business sales is going to be negatively influenced by headlines which weren?t written to entice people. In the event the headline is just not direct, many readers will just hop over your website; if the headline just isn?t sufficiently strong enough to convey your point, the product?s USP will probably be misunderstood. Sales may also plummet with a headline that is too bland, or too out of place. Make sure an ineffective headline isn?t the downfall for your business.

You must never attempt to write copy for something that you have no knowledge about when you are not able to it.

It really does become apparent you don?t know what you really are speaking about for those who have done no research. This will make your audience lose rely upon that which you wrote. Regardless of what sort of writing you are doing, you need to do your research. However, while you commence to copy write, you will need to ensure that the details you?ve got is quality when covering an item. Should you end up having bad facts it reflects badly on you.

Last however, not the very least, take into account that your copy could eventually select how many sales you receive and what degree your internet business grows. Give full attention to producing the most effective copies possible and check out them out to determine the top technique for your organization.

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Copywriting Missteps That You Ought To Attempt To Avoid

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One of the best solutions to improve any Online business is that will put out some excellent copywriting which will draw an excellent audience. You know that words sell and when you can write a good copy then you can definitely develop a fortune together with your business. Particularly when looking at direct response selling or search engine optimisation, in the world of internet marketing, copy is king. Whether it's MLM, selling physical products on the internet, or your service, you need to write so that people get convinced to buy within you. It isn't even necessary to be as careful of the grammar that you just learned while in school when copywriting. You need to actually write like you speak; that way as soon as your target group is reading whatever you wrote, they feel as if you are actually speaking with them. Like all disciplines, there are numerous guidelines that really must be followed to write down effectual copy. In terms of landing your prospective buyers, you simply can't risk making any mistakes. In this post we'll be researching tips on how to avoid making common copywriting mistakes.

In today's world, consumers want up to date information they will can immediately utilized. They would like to have the information quickly, so guarantee the copy grabs their attention. Thus, making this why, when you wish to carry the interest of the reader, you should concentrate on making a great headline to your copy. Titles are likely to be overlooked until the eleventh hour by many copywriters-- certainly one of the biggest errors they could make. In order to pointedly direct the crowd to your article and supply advisable of the items there are here, effective headlines include the only formula for achievement. A dull headline which only bores people may be the worst mistake a copywriter might make. A big extent of the sales will go directly to you, exclusively due to your headline. It's because of this that this quality of your respective headline is of supreme importance and should get significant consideration. Business sales is going to be negatively influenced by headlines which weren't written to entice people. In the event the headline is just not direct, many readers will just hop over your website; if the headline just isn't sufficiently strong enough to convey your point, the product's USP will probably be misunderstood. Sales may also plummet with a headline that is too bland, or too out of place. Make sure an ineffective headline isn't the downfall for your business.

You must never attempt to write copy for something that you have no knowledge about when you are not able to it.

It really does become apparent you don't know what you really are speaking about for those who have done no research. This will make your audience lose rely upon that which you wrote. Regardless of what sort of writing you are doing, you need to do your research. However, while you commence to copy write, you will need to ensure that the details you've got is quality when covering an item. Should you end up having bad facts it reflects badly on you.

Last however, not the very least, take into account that your copy could eventually select how many sales you receive and what degree your internet business grows. Give full attention to producing the most effective copies possible and check out them out to determine the top technique for your organization.

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Damascus rocked by 'most intense' fighting of revolt

Syria's army blasted rebel strongholds in Damascus with mortars Sunday, sparking the "most intense" fighting in the capital since the revolt erupted 16 months ago, a monitoring group said.

The army's offensive, aimed at driving rebels of the Free Syrian Army (FSA) out of Damascus, was launched soon after the foreign ministry held a press conference to deny its troops had carried out a massacre in Treimsa village.

"The regular army fired mortar rounds into several suburbs" where FSA rebels are entrenched, said Rami Abdel Rahman, head of the Syrian Observatory for Human Rights.

The fighting was heaviest in the Tadamon, Kfar Sousa, Nahr Aisha and Sidi Qadad neighbourhoods, he said. Six civilians were reported killed in the city.

"(It has) never been this intense," Abdel Rahman told AFP.

"The security forces are attempting to take control of these neighbourhoods but so far they have not succeeded," he added.

The Local Coordination Committees, which organise anti-regime protests in Syria, said plumes of black smoke were billowing out of Tadamon late Sunday and that loud explosions had been heard in Nahr Aisha.

The Britain-based Observatory said violence across Syria on Sunday had killed 105 people -- 48 civilians, 16 rebels and 41 soldiers.

The main opposition coalition, the Syrian National Council (SNC), hailed the insurgents fighting army troops in the capital, accusing the regime of having transformed rebel neighbourhoods into "a battlefield."

"The revolution is spreading and has tightened the noose around the regime in zones where it thought it was beyond the anger of the people," SNC spokesman Georges Sabra said in a speech shown on Arab satellite networks.

"We place on the Arab League and the international community the responsibility for any disastrous result from what is going on in Homs and Damascus," he added.

Rights activists say more than 150 people were massacred by Syrian troops backed by pro-regime shabiha militiamen on Thursday in the central village of Treimsa.

If the number is confirmed, this would be one of the bloodiest episodes of the uprising against President Bashar al-Assad, which rights activists say has cost more than 17,000 lives since March 2011.

But foreign ministry spokesman Jihad Makdissi vehemently denied both the allegations of a massacre and the number of people reportedly killed.

"What happened was not a massacre ... It was a clash between regular forces and armed groups who do not believe in a peaceful solution," Makdissi told reporters in Damascus.

Makdissi also denied activists' allegations that helicopters and heavy weapons had been used in the assault on Treimsa.

"This is absolutely not true. Only troop carriers and light weapons were used, the most powerful of weapons being RPGs (rocket-propelled grenades)," he said.

Makdissi said "only five buildings, where there were very sophisticated weapons, were targeted".

And dismissing allegations of more than 150 killed, he said that "37 armed men were killed and two civilians only", citing an unidentified source who claimed to have buried them.

The UN Supervision Mission in Syria said a team of "specialised civilian and military experts" had visited Treimsa on Sunday to continue their investigation into the reports of the mass killing.

"The integrated patrol ... observed over 50 houses that were burned and/or destroyed. Pools of blood and brain matter were observed in a number of homes," UNSMIS spokeswoman Sausan Ghosheh said in a statement.

"On the basis of some of the destruction observed in the town and the witness accounts, the attack appears targeted at army defectors and activists," she added.

"The number of casualties is still unclear."

The Treimsa incident has galvanised international diplomatic efforts over the crisis.

On Monday, UN-Arab League envoy Kofi Annan and UN Secretary General Ban Ki-moon are headed respectively for Russia and China to press the two UN Security Council members to back tougher action against Assad's regime.

The visits by Annan and Ban come at a crucial new stage in the conflict.

The Security Council has until Friday to renew the UN mission in Syria but is divided over Western calls to add sanctions.

"So divided that maybe Annan and Ban now have the most influence over Russia and China to get anything done," said one senior UN council diplomat, speaking on condition of anonymity.

A draft statement which said the Syria government was in "violation" of its international commitments was circulated among the 15 Council nations on Friday, diplomats said.

Russia's envoys said they could not agree. Russia has led the resistance and Annan was to meet President Vladimir Putin and Foreign Minister Sergei Lavrov during two days of talks in Moscow, said his spokesman Ahmad Fawzi.

China has supported Russia's position and Ban heads for Beijing on Monday, officially for a China-Africa summit.

But Syria will top his agenda when he meets President Hu Jintao and other senior leaders, said a UN official.

Source: http://news.yahoo.com/syrian-troops-storm-town-amid-calls-un-action-104507895.html

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