Heidi Klum Poses Nude For Allure & Discusses Split From Seal

Heidi Klum Poses Nude For Allure & Discusses Split From Seal

Heidi Klum, the 38-year-old model and “Project Runway” host posed in her birthday suit for Allure, discussing her marital split and cosmetic surgery. Heidi insists [...]

Heidi Klum Poses Nude For Allure & Discusses Split From Seal Stupid Celebrities Gossip Stupid Celebrities Gossip News


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Londoners mourn as teletext goes dark, a victim of the DTV transition

Londoners mourn as Teletext goes dark, a victim of the DTV transition

Despite the many advantages of digital broadcast television, the transition is separating Europeans from a reliable source of information known as teletext. Citizens of London are the latest to experience the loss, as analog signals in the region were switched off just yesterday. Ceefax, a service of the BBC, has provided millions of Britons with news, sports, weather, television listings, subtitles and games for the past 38 years, and is now accessible only in Kent, Sussex, north-east England and Northern Ireland. Soon, it may cease to exist altogether.

Seen as a precursor to the internet, teletext is a free service that's heavily rooted in analog PAL signals, where small packets of data are sent in the vertical blanking interval, which is otherwise unnoticed by viewers. Because the information is broadcast, users were never subject to network congestion, and only needed to wait a brief moment for their desired page to be transmitted -- more advanced televisions even cached this information locally. As part of the airwaves, the service is naturally free, and in that sense, it lacks a suitable replacement. As with all progress, however, there are casualties, and teletext was an unfortunate bystander. Those who cherished the service can take a moment to relive the memories in the links below.

Londoners mourn as teletext goes dark, a victim of the DTV transition originally appeared on Engadget on Thu, 19 Apr 2012 00:42:00 EDT. Please see our terms for use of feeds.

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Unified Communications: An Integrator's Dream | Channelnomics

A staple of modern business is communications. A business simply cannot exist without connecting with suppliers, partners and customers. The challenge isn?t having communications, but rather controlling the plethora of communications channels ? telephony, video conferencing, instant messaging, collaboration tools, email, portals and mobile devices, to name a few.

Unified communications holds the promise of bringing all these disparate tools together to make the conveyance of information easier and lead to higher levels of productivity and effectiveness.

The trouble facing the channel: There?s no such thing as a unified communications product despite the fact businesses will spend more than $27 billion on such technology this year.

Reconciling this notion of a huge marketplace and no product was the task given to me by the CompTIA Unified Communications Community, who asked me to speak at its meeting last week in Chicago. Initially, I was going to talk about the evolution of the social enterprise, the use of social tools like Twitter and Facebook in place of telephones and email. I did keep that message, but called an audible at the last minute to expand the discussion to the communications challenges of businesses.

The average business user receives 100 to 125 emails per day. Layer on that the number of phone calls, text messages and tweets, and that?s a lot of communication. But it doesn?t begin to take in the true volume until meetings ? particularly remote meetings facilitated by services such as Citrix GoToMeeting or Cisco Webex ? are taken into consideration. And what about all those documents passed back and forth via email, servers and file sharing services? That?s a form of communication, too.

The volume is simply fantastic, as are the options for delivering and managing these communiques.

While many ?unified communications? vendors offer products that integrate telephony and applications, collaboration and video, instant messaging and social networks, communications and business applications, none offers a product under a ?single pane of glass? with all the communications tools that are easily accessible, usable and affordable.

This isn?t alien to the industry, either. The definition of unified communications spells it out clearly:

?Unified communications is the integration of real-time communication services such as instant messaging, presence information, telephony, video conferencing, data sharing (including web-connected electronic whiteboards, aka IWB?s or Interactive White Boards), call control and speech recognition with non-real-time communication services such as unified messaging (integrated voicemail, e-mail, SMS and fax). UC is not necessarily a single product, but a set of products that provide a consistent unified user interface and user experience across multiple devices and media types. There have been attempts at creating a single product solution however the most popular solution is dependent on multiple products.? (Thank you, Wikipedia)

And that definition makes unified communications an integrator?s dream. Solution providers can mix and match technologies to create solutions tailored to customers, verticals, market segments and price points. There are so many suppliers ? Cisco, Microsoft, Avaya, Polycom, ShoreTel, LifeSize, Adtran, etc. ? that solution providers can literally build systems that use vendor components in systems that become their brand.

The open definition of unified communications makes it a unique platform in which the message isn?t the technology sold into the customer environment, but rather how the technology delivers an outcome desired by the customer. Consider this: A small business says it has unified communications because it has softphones installed on all its PCs alongside, but not integrated with, a third-party instant messaging application. Is that unified communications? A purist would say no, but the simple answer is yes because it meets the customer?s need and budget.

Now, consider the possibilities of open unified communications. A law firm wants a phone system integrated with CRM. The intent is to track all calls and automate billing against accounts, which requires integration with the finance system. And since not all communications are done by phone, email and instant messaging must be integrated into the system, as well. This goes beyond unified communications to integrated business solutions. If you think this is fanciful, guess again. This is a real example provided by a telephony solution provider.

The channel needs to stop thinking of unified communications as a product and start thinking of it as an outcome. By designing systems with independently developed intellectual property that leverages vendor technologies as building blocks, solution providers can create a robust, branded communications solution that advances their customers? productivity and profitability. Now that?s the promise of unified communications.

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Stanford-spawned nanoparticles home in on brain tumors, boost ...

Abstract:
Like special-forces troops laser-tagging targets for a bomber pilot, tiny particles that can be imaged three different ways at once have enabled Stanford University School of Medicine scientists to remove brain tumors from mice with unprecedented accuracy.

Stanford, CA | Posted on April 16th, 2012

In a study to be published online April 15 in Nature Medicine, a team led by Sam Gambhir, MD, PhD, professor and chair of radiology, showed that the minuscule nanoparticles engineered in his lab homed in on and highlighted brain tumors, precisely delineating their boundaries and greatly easing their complete removal. The new technique could someday help improve the prognosis of patients with deadly brain cancers.

About 14,000 people are diagnosed annually with brain cancer in the United States. Of those cases, about 3,000 are glioblastomas, the most aggressive form of brain tumor. The prognosis for glioblastoma is bleak: the median survival time without treatment is three months. Surgical removal of such tumors ? a virtual imperative whenever possible ? prolongs the typical patient's survival by less than a year. One big reason for this is that it is almost impossible for even the most skilled neurosurgeon to remove the entire tumor while sparing normal brain.

"With brain tumors, surgeons don't have the luxury of removing large amounts of surrounding normal brain tissue to be sure no cancer cells are left," said Gambhir, who is the Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research and director of the Molecular Imaging Program at Stanford. "You clearly have to leave as much of the healthy brain intact as you possibly can."

This is a real problem for glioblastomas, which are particularly rough-edged tumors. In these tumors, tiny fingerlike projections commonly infiltrate healthy tissues, following the paths of blood vessels and nerve tracts. An additional challenge is posed by micrometastases: minuscule tumor patches caused by the migration and replication of cells from the primary tumor. Micrometastases dotting otherwise healthy nearby tissue but invisible to the surgeon's naked eye can burgeon into new tumors.

Although brain surgery today tends to be guided by the surgeon's naked eye, new molecular imaging methods could change that, and this study demonstrates the potential of using high-technology nanoparticles to highlight tumor tissue before and during brain surgery.

The nanoparticles used in the study are essentially tiny gold balls coated with imaging reagents. Each nanoparticle measures less than five one-millionths of an inch in diameter ? about one-sixtieth that of a human red blood cell.

"We hypothesized that these particles, injected intravenously, would preferentially home in on tumors but not healthy brain tissue," said Gambhir, who is also a member of the Stanford Cancer Institute. "The tiny blood vessels that feed a brain tumor are leaky, so we hoped that the spheres would bleed out of these vessels and lodge in nearby tumor material." The particles' gold cores, enhanced as they are by specialized coatings, would then render the particles simultaneously visible to three distinct methods of imaging, each contributing uniquely to an improved surgical outcome.

One of those methods, magnetic resonance imaging, is already frequently used to give surgeons an idea of where in the brain the tumor resides before they operate. MRI is well-equipped to determine a tumor's boundaries, but when used preoperatively it can't perfectly describe an aggressively growing tumor's position within a subtly dynamic brain at the time the operation itself takes place.

The Gambhir team's nanoparticles are coated with gadolinium, an MRI contrast agent, in a way that keeps them stably attached to the relatively inert spheres in a blood-like environment. (In a 2011 study published in Science Translational Medicine, Gambhir and his colleagues showed in small animal models that nanoparticles similar to those used in this new study, but not containing gadolinium, were nontoxic.)

A second, newer method is photoacoustic imaging, in which pulses of light are absorbed by materials such as the nanoparticles' gold cores. The particles heat up slightly, producing detectable ultrasound signals from which a three-dimensional image of the tumor can be computed. Because this mode of imaging has high depth penetration and is highly sensitive to the presence of the gold particles, it can be useful in guiding removal of the bulk of a tumor during surgery.

The third method, called Raman imaging, leverages the capacity of certain materials (included in a layer coating the gold spheres) to give off almost undetectable amounts of light in a signature pattern consisting of several distinct wavelengths. The gold cores' surfaces amplify the feeble Raman signals so they can be captured by a special microscope.

To demonstrate the utility of their approach, the investigators first showed via various methods that the lab's nanoparticles specifically targeted tumor tissue, and only tumor tissue.

Next, they implanted several different types of human glioblastoma cells deep into the brains of laboratory mice. After injecting the imaging-enhancing nanoparticles into the mice's tail veins, they were able to visualize, with all three imaging modes, the tumors that the glioblastoma cells had spawned.

The MRI scans provided good preoperative images of tumors' general shapes and locations. And during the operation itself, photoacoustic imaging permitted accurate, real-time visualization of tumors' edges, enhancing surgical precision.

But neither MRI nor photoacoustic imaging by themselves can distinguish healthy from cancerous tissue at a sufficiently minute level to identify every last bit of a tumor. Here, the third method, Raman imaging, proved crucial. In the study, Raman signals emanated only from tumor-ensconced nanoparticles, never from nanoparticle-free healthy tissue. So, after the bulk of an animal's tumor had been cleared, the highly sensitive Raman-imaging technique was extremely accurate in flagging residual micrometastases and tiny fingerlike tumor projections still holed up in adjacent normal tissue that had been missed on visual inspection. This, in turn, enabled these dangerous remnants' removal.

"Now we can learn the tumor's extent before we go into the operating room, be guided with molecular precision during the excision procedure itself and then immediately afterward be able to 'see' once-invisible residual tumor material and take that out, too," said Gambhir, who suggested that the nanoparticles' propensity to heat up on photoacoustic stimulation, combined with their tumor specificity, might also make it possible for them to be used to selectively destroy tumors. He also expressed optimism that this kind of precision could eventually be brought to bear on other tumor types.

The study was funded by the National Institutes of Health, the National Cancer Institute's Center for Cancer Nanotechnology Excellence, the Ben and Catherine Ivy Foundation, the Canary Foundation and the Leon Levy Foundation.

Sharing first authorship were Moritz Kircher, MD, PhD, and postdoctoral scholar Adam de La Zerda, PhD. Some of the animal work was carried out through a collaboration with researchers at Memorial Sloan-Kettering Cancer Center (where Kircher is now employed) and at Weill-Cornell Medical College, both in New York City. Additional Stanford co-authors were postdoctoral scholars Jesse Jokerst, PhD, and Cristina Zavaleta, PhD; clinical instructor Erik Mitra, MD, PhD; and research scientist Frezghi Habte, PhD, all of the Department of Radiology; and Robert Sinclair, PhD, professor and chair of materials science and engineering in the School of Engineering, and his graduate student Paul Kempen.

####

About Stanford University Medical Center
The Stanford University School of Medicine consistently ranks among the nation's top medical schools, integrating research, medical education, patient care and community service.

For more information, please click here

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News and information

Nano-Syringe Delivers Combination, Targeted Brain Cancer Therapy April 17th, 2012

Quantenna Communications Raises $79 Million Led by RUSNANO and Sequoia Capital: Oversubscribed Funding Round to Help Extend Quantenna?s Technology and Market Leadership in Ultra-Reliable Video-over-Wi-Fi April 17th, 2012

The Photonex London Roadshow opens its doors at Imperial College on Thursday 26th April ? intensive conference and tutorial programme backed with an equipment exhibition all under one roof April 17th, 2012

Government of Canada Invests in Mississauga Nanotechnology Firm: Integran's research will lead to innovative new aerospace and defence products April 16th, 2012

Seventh International Workshop on Nano-scale Spectroscopy and Nanotechnology, Zurich, Switzerland April 16th, 2012

Imaging

Seventh International Workshop on Nano-scale Spectroscopy and Nanotechnology, Zurich, Switzerland April 16th, 2012

ORNL microscopy inspires flexoelectric theory behind 'material on the brink' April 14th, 2012

Tumor study reveals size limitations for new drugs: Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines April 10th, 2012

Govt.-Legislation/Regulation/Funding/Policy

Government of Canada Invests in Mississauga Nanotechnology Firm: Integran's research will lead to innovative new aerospace and defence products April 16th, 2012

Nanosponges soak up oil again and again: Rice, Penn State nanotube blocks show promise for environmental cleanup, among many uses April 16th, 2012

ORNL microscopy inspires flexoelectric theory behind 'material on the brink' April 14th, 2012

Ferroelectric oxides do the twist April 11th, 2012

Nanomedicine

Nano-Syringe Delivers Combination, Targeted Brain Cancer Therapy April 17th, 2012

Medistem Industry/Academia Collaboration Leads to Nanotechnology Based "Cancer Vaccine": Peer-Reviewed Publication Demonstrates New Method of Treating Prostate Cancer Based on Nanoparticle-Loaded Dendritic Cells April 14th, 2012

Nano-sized ?factories? churn out proteins: Tiny particles could manufacture cancer drugs at tumor sites April 11th, 2012

Tumor study reveals size limitations for new drugs: Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines April 10th, 2012

Discoveries

Nano-Syringe Delivers Combination, Targeted Brain Cancer Therapy April 17th, 2012

UWM discovery advances graphene-based electronics April 16th, 2012

Nanosponges soak up oil again and again: Rice, Penn State nanotube blocks show promise for environmental cleanup, among many uses April 16th, 2012

Nanoscientists find long-sought Majorana particle April 16th, 2012

Announcements

Nano-Syringe Delivers Combination, Targeted Brain Cancer Therapy April 17th, 2012

Quantenna Communications Raises $79 Million Led by RUSNANO and Sequoia Capital: Oversubscribed Funding Round to Help Extend Quantenna?s Technology and Market Leadership in Ultra-Reliable Video-over-Wi-Fi April 17th, 2012

The Photonex London Roadshow opens its doors at Imperial College on Thursday 26th April ? intensive conference and tutorial programme backed with an equipment exhibition all under one roof April 17th, 2012

Nanoscientists find long-sought Majorana particle April 16th, 2012

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

DA NanoMaterials L.L.C. Receives Intel's Preferred Quality Supplier Award April 11th, 2012

Writers of the Future: As Science Fiction Becomes Science Fact: Once envisioned through the eyes of writers such as Isaac Asimov, Hugo Gersnsback, Robert Heinlein and L. Ron Hubbard, science fiction is indeed becoming science fact April 9th, 2012

CNSE Student Honored with Nation's Most Prestigious Undergraduate Award for Scientific Study: In receiving 2012 Barry M. Goldwater Scholarship, CNSE sophomore Sheila Smith is believed to be the first ever to be recognized in the field of nanotechnology April 9th, 2012

$110,000 NewSpace 2012 Business Plan Competition Reaches Out to Nano- and Biotech Entrepreneurs April 6th, 2012

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Matt Lauer Fathered ?Today Show? Co-Anchor Natalie Morales? Child?

Matt Lauer Fathered “Today Show” Co-Anchor Natalie Morales’ Child?

There have been rumors of Matt Lauer’s philandering ways for years. Now there are reports that Lauer has a love child with his co-worker that [...]

Matt Lauer Fathered “Today Show” Co-Anchor Natalie Morales’ Child? Stupid Celebrities Gossip Stupid Celebrities Gossip News


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PPC Advertising - Benefits and Management

A type of online advertising where payment to the particular website or search engine is done based on the qualified 'click-through' of your PPC ads. This technique is known as PPC advertising where the company has to pay a pre-decided amount for each click that is linked to his site based on a specific search query or term by the visitors. This is one of the types of internet marketing instrument and it is a technique to promote the websites of companies who want to deal through the internet. Various benefits of this method include:

? ?Increases the company's brand name and easily get the prospective customer through such technique
? ?There is an option to modify advertisements and promoting through the internet can help increase a company's branding
? ?The advertisers charge money only when a user visits the website and clicks its advertisement

Any industry associated with internet marketing is aware about this term.

For those who are new to it, PPC can be defined as the process in which you make ?bid? for specific keywords that is related to your website or your industry on the search engines like Google Adwords, MSN and Yahoo Search Marketing. For Pay per Click campaigns management, the keywords or key phrases should be selected wisely as you acquire the conversion depending on the keywords selected. It is always good in getting your site listed in the sponsored listings of the search engines for the competitive keywords and always keeps a track on your campaigns throughout.

Such campaigns are profitable only if you get to earn good conversions and the most excellent way to make your pay per click campaign booming is to hire a professional Pay per Click Company.

But do remember to check out the type of projects handled and conversions done by them by doing the referral checks. It is always a financially good idea to do complete research and then decide to choose them.

Another name of the highly effective process is Cost per click (CPC), which can determine the CTR (Click through Rate). This effectual and strategic PPC advertising management can turn the business around without ruining the image in the fight for online rank and position. When targeted appropriately can prove to enlarge up the profits incredibly and the PPC experts manage the most popular PPC advertising vehicles namely Google Ad words and Yahoo Search Marketing in the most efficient manner, making sure the success of your PPC Campaigns and maximizing your ROI. This give an immense scope for advertisers to list their websites as search results caused in response to a meticulous search query matching to the subject of the search listing.

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HTC launches trio of Dragons in China, Ice Cream Sandwich on all

HTC launches trio of Dragons in China, Ice Cream Sandwich on all
HTC's been far from quiet since unveiling its One series to the masses, and today the company's continuing the trend by launching three new devices in China. This trio makes up HTC's Dragon lineup, which our partners at Engadget China first met at MWC. Leading the way is the 4-inch HTC VT T328t for China Mobile, featuring Sense 4, an S-LCD, WVGA screen, a 1GHz CPU alongside 512MB of RAM, the famed Beats Audio and of course, it's running a flavor of Android ICS. As for the VC T328d (Telecom) and V T328w (Unicom), they're both rocking similar specs as the VT model, with the exception of dual-SIM card slots on each. All three Dragons are expected to be available by month's end, but save for the T328w costing 1999 yuan (around $320), pricing remains a mystery.

Continue reading HTC launches trio of Dragons in China, Ice Cream Sandwich on all

HTC launches trio of Dragons in China, Ice Cream Sandwich on all originally appeared on Engadget on Sat, 14 Apr 2012 03:27:00 EDT. Please see our terms for use of feeds.

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